Topical Pain Creams for Management of Acute, Chronic, and Neuropathic Pain
Pain is one of the most common reasons people consult with a physician. Recent advances in the knowledge of the different type of pain receptors and their locations in the body, allows for the use of combinations of medication, which work synergistically, and at smaller individual doses to achieve optimum pain relief. One of the most exciting new concepts in pain management is the use of transdermal (topical) medications.
Transdermal delivery allows a convenient, noninvasive, way to manage difficult types of pain. Side effects and drug interactions are minimized because, unlike oral medications that require high blood levels to achieve effectiveness, topical creams are designed to provide high tissue concentrations without significant blood levels. Medication is targeted directly to the site of injury, greatly increasing a drug’s effectiveness. With topical delivery, drug absorption through the skin is slower and tissue levels remain higher for longer periods – providing a sustained activity effect. Medicine taken orally must first be processed through the liver. Another advantage of topically delivery is that the drugs are not metabolized by the liver. This is favorable for elderly patients or those patients with pre-existing liver disease.
Specially blended topical pain formulations, using a combination of medications to block multiple pain receptors, have been used successfully in the management of the following painful conditions: